Registration Dossier
Registration Dossier
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EC number: 255-259-4 | CAS number: 41200-97-9
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP screening study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Principles of method if other than guideline:
- Mouse local lymph node assay (LLNA)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- 1,5-dichloro-2-(1-methylethoxy)-4-nitrobenzene
- EC Number:
- 255-259-4
- EC Name:
- 1,5-dichloro-2-(1-methylethoxy)-4-nitrobenzene
- Cas Number:
- 41200-97-9
- Molecular formula:
- C9H9Cl2NO3
- IUPAC Name:
- 1,5-dichloro-2-nitro-4-(propan-2-yloxy)benzene
- Details on test material:
- - Name of test material (as cited in study report): 2,4-dichloro 5-isopropoxy nitrobenzene (DINB)
- Storage condition of test material: stored in the dark at room temperature in air-tight containers
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
Results and discussion
Any other information on results incl. tables
No indication of the test results provided
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, 1,5-Dichloro-2-(1-methylethoxy)-4-nitrobenzene is not a skin sensitiser in the mouse local lymph node assay.
- Executive summary:
In a mouse local lymph node assay performed in compliance with the GLP, 1,5-Dichloro-2-(1-methylethoxy)-4-nitrobenzene (named as2,4-dichloro 5-isopropoxy nitrobenzene(DINB)) has no skin sensitisation potential. It is therefore not classified for skin sensitisation according to the Regulation (EC) 1272/2008 and the Directive 67/548/EEC.
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