Registration Dossier
Registration Dossier
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EC number: 242-262-0 | CAS number: 18379-25-4
Endpoint summary
Administrative data
Description of key information
Only one acute toxicity study is available for trichloro (2,4,4-trimethypentyl)silane. In a reliable oral study, conducted in accordance with OECD 423 (acute toxic class method) the LD50 for rats was determined to be in the range 25-200 mg/kg when dosed in corn oil. Slight to moderate reduced motiltiy, ataxia and dyspnoea, slightly reduced muscle tone or adopting a lateral or abdominal postition were noted in all animals of the 2000 mg/kg bw group.
There are no data for dermal and inhalation routes.
Key value for chemical safety assessment
Additional information
This is the only study available for acute toxicity.
Justification for classification or non-classification
On the basis of the available measured oral LD50 value, trichloro(2,4,4-trimethypentyl)silane is classified R22 'Harmful if swallowed', according to the criteria of EU Directive 67/548/EEC and 'Acute toxic 3 (oral)' under Regulation 1272/2008.
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