Registration Dossier
Registration Dossier
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EC number: 242-262-0 | CAS number: 18379-25-4
Endpoint summary
Administrative data
Description of key information
The key skin irritatation/corrosion study (Allied Signal, 1995) was conducted following a method that was similar to OECD 404. Trichloro (2,4,4-trimethylpentyl)silane was determined to be corrosive to rabbit skin following a three minute exposure to the neat test substance. Based on the outcome of the skin study, in accordance with Column 2 of REACH Annex VIII, the in vivo eye irritation study is not required.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
The key skin irritation/corrosion study is the only available study for that endpoint. Trichloro (2,4,4-trimethylpentyl)silane was determined to be corrosive to rabbit skin following a three minute exposure to the neat test substance.
Effects on skin irritation/corrosion: corrosive
Effects on eye irritation: corrosive
Effects on respiratory irritation: highly irritating
Justification for classification or non-classification
Based on the available in vivo skin study, Trichloro (2,4,4-trimethylpentyl)silane is classified R35 "Corrosive" according to EU Directive 67/548/EEC and "Skin Corr. 1A" under Regulation 1272/2008.
Consistent with other chlorosilanes, the additional classification of EUH0 71 "Corrosive to respiratory tract" is also proposed.
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