Registration Dossier
Registration Dossier
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EC number: 221-657-1 | CAS number: 3179-47-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
There is no information concerning the skin sensitising potential for n-Decyl methacrylate available. The results of skin sensitisation studies of the structurally closely related Isodecyl methacrylate (i-C10-Ester) are considered as representative for the skin sensitising toxicity of n-Decyl methacrylate (n-C10 -Ester).
Isodecyl methacrylate was demonstrated to be not sensitising in a fully valid GLP guideline study according to OECD 429. So we expect n-Decyl methacrylate to be a non-sensitiser as well.
Migrated from Short description of key information:
There is no information concerning the skin sensitising potential for n-Decyl methacrylate available. The results of skin sensitisation studies of the structurally closely related Isodecyl methacrylate (i-C10-Ester) are considered as representative for skin sensitising toxicity of n-Decyl methacrylate (n-C10 -Ester).
Isodecyl methacrylate was demonstrated to be not sensitising in a fully valid GLP guideline study according to OECD 429 (LLNA assay). So we expect n-Decyl methacrylate to be none sensitising as well.
Justification for selection of skin sensitisation endpoint:
There is no information concerning the skin sensitising potential for n-Decyl methacrylate available. The results of skin sensitisation studies of the structurally closely related Isodecyl methacrylate (i-C10-Ester) are considered as representative for the skin sensitising toxicity of n-Decyl methacrylate (n-C10 -Ester). Only one study available for Isodecyl methacrylate.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
According to the criteria as of directive 1272/2008/EC, no classification is warranted.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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