Registration Dossier
Registration Dossier
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EC number: 424-090-1 | CAS number: 10097-02-6 DMBA
Endpoint summary
Administrative data
Description of key information
Hydrolysis
The study of determination of Hydrolysis as a Function of pH was performed as a preliminary test according to 92/69/EEC, C7 (OECD 111). The substance was found to be hydrolytically stable under acidic, neutral and basic conditions.
The dissipation DT50 of parent compound was established as follow: DT50 at pH = 4 was more than 8760 hours; DT50 at pH = 7 was more than 8760 hours; DT50 at pH = 9 was more than 8760 hours.
Biodegradation
The key study was performed toOECD 301 C Modified MITI Test.The test material was tested at a concentration of 100 mg/L and the inoculum was activated sludge (mixed liquor suspended solids: 3550 mg/L). The degradation of the test substance was assessed by the determination of Biochemical oxygen demand (BOD) for 28 days and measurements of dissolved organic carbon (DOC) and residual test substance (by gas chromatography) on Day 28. The test treatment was measured in triplicate and one vessel for each of activity control (aniline + sludge + basal medium), abiotic control (test substance + deionised water) and inoculum blank (sludge + basal medium) were taken.
The average biodegradation values of DMBA were 6, 15 and 12 %, based on BOD, DOC and residual test substance, respectively. From the degradability results based on the BOD, it was concluded that the test substance is not readily biodegradable under the conditions of the modified MITI test. It was suggested that degradation of the test substance continued in one of three test vessels. Therefore, once microorganisms were acclimated and biodegradation was started, the test substance may be degraded completely without making transformed products. However, it would be required much time to degrade the test substance completely.
Bioaccumulation
According to result from QSAR study on adsorption/desorption using KOCWIN v2.00; MCI method (EPISUITE v 4.11), the substance falls within the applicability domain (2,2-bis(hydroxymethyl) butanoic acid is organic monoconstituent substance with molecular weight of 148.16) and therefore the predicted value (Koc: 10.0 L/kg, Log Koc: 1.0) can be considered as reliable taking into account the statistical information for the MCI (Molecular Connectivity Index, first-order) training and validation datasets. The predicted value was used for Chemical safety assessment (CSA) and is considered as adequate and no additional information is required.
Additional information
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