Registration Dossier
Registration Dossier
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EC number: 202-605-7 | CAS number: 97-74-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Effet sur le systeme nerveux central du monosulfure de tetramethylthiurame comparaison avec le disulfirame.
- Author:
- Poitou, P. Marignac, B. et Gradiski, D.
- Year:
- 1 978
- Bibliographic source:
- J.Pharmacol., 9/1, 35-44.
Materials and methods
- Principles of method if other than guideline:
- Rats were treated with TMTM by ip.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Tetramethylthiuram monosulphide
- EC Number:
- 202-605-7
- EC Name:
- Tetramethylthiuram monosulphide
- Cas Number:
- 97-74-5
- Molecular formula:
- C6H12N2S3
- IUPAC Name:
- N,N-dimethyl[(dimethylcarbamothioyl)sulfanyl]carbothioamide
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: EVIC CEBA
- Age at study initiation:
- Weight at study initiation: 200g
- Fasting period before study:
- Housing:
- Diet (e.g. ad libitum):
- Water (e.g. ad libitum):
- Acclimation period:
ENVIRONMENTAL CONDITIONS
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light):
IN-LIFE DATES: From: To:
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Details on exposure:
- Administration volume = 5 ml/kg
- Doses:
- no data
- No. of animals per sex per dose:
- 10 animals /dose/sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- ANOVA method
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 383 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 361 - 403
- Mortality:
- no data
- Clinical signs:
- hypothermia, hypoactivity
- Body weight:
- no data
- Gross pathology:
- no data
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
