Registration Dossier
Registration Dossier
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EC number: 231-472-8 | CAS number: 7575-23-7
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: QSAR estimations from dermal absorption tend to be conservative; however, they are not formally validated
Data source
Reference
- Reference Type:
- other: database
- Title:
- Danish QSAR Database
- Author:
- Anonymous
- Bibliographic source:
- http://ecbqsar.jrc.it/
Materials and methods
- Principles of method if other than guideline:
- The Danish QSAR Database reports DERMWINv.2 calculations. These are based on the Guy & Potts formula (GUY R.H. AND POTTS R.O., 1992. Structure-Permeability Relationships in Percutaneous absorption. J. Pharm. Sci.. 81: 603-604).
Test material
- Reference substance name:
- Pentaerythritol tetrakis(3-mercaptopropionate)
- EC Number:
- 231-472-8
- EC Name:
- Pentaerythritol tetrakis(3-mercaptopropionate)
- Cas Number:
- 7575-23-7
- Molecular formula:
- C17H28O8S4
- IUPAC Name:
- 3-[(3-sulfanylpropanoyl)oxy]-2,2-bis({[(3-sulfanylpropanoyl)oxy]methyl})propyl 3-sulfanylpropanoate
Constituent 1
Results and discussion
Percutaneous absorption
- Parameter:
- percentage
- Absorption:
- <= 10 %
- Remarks on result:
- other: 8 h
- Remarks:
- Concluded on the basis of the very low predicted absorption rate of 0.00001 mg/cm²/event.
Applicant's summary and conclusion
- Conclusions:
- It is concluded that absorption of PETMP through human skin in vivo within 8 h will be significantly less than 10%. This is a very conservative assumption that will be used for dermal risk assessments.
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