Registration Dossier
Registration Dossier
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EC number: 942-177-5 | CAS number: -
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3
Reference
Description of key information
Higest data used in the chemical safety assessment.
Based on Log Pow the partition coefficient of the substance te BCF is considered to be <0.36 - 274.28 L/Kg.
A partition coefficient in excess of 4.5 is considered to be of concern as potential for bioaccumulation, according to screening criteria for bioaccummulation in ECHA guidance (Chapter R.11 PBT Assessment).
The likely reliability of the log Pow is, however, considered to diminish above a value of 6, as noted in Appendix R.11-1 Annex 1 of ECHA guidance on PBT Assessment. Substances with log Pow between 4.5 and 6 are considered likely to be highly accumulating; however no substantial bioconcentration is assumed for compounds having log Pow with values less than 4.5 or greater than 6. For compounds having log Pow greater than 6, a gradual decrease of the BCF is observed and it has been hypothesised within the published literature that a high log Pow is more an effect of solubility than a tendency of the substance to be lipophilic.
This is further supported by the estimation based on the linear correlation used from ECHA technical guidance: Chapter R.7c: Endpoint specific guidance [Veith, G.D., et al. (1979)]the highest BCF is 274.28, considerably below the threshold of concern derived by the REACH criteria of 2000 (B) and 5000 (vB).
Furthermore, controls required for the use of the material are designed ensure no exposure of the substance to the aquatic environment removing any opportunity for bioaccumulation.
It is therefore considered that the substance is considered to not have the potential to bioaccumulate and it is therefore not scientifically justified to undertake a study in fish.
Key value for chemical safety assessment
- BCF (aquatic species):
- 2.43 dimensionless
- BMF in fish (dimensionless):
- 1
Additional information
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