Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 266-235-8 | CAS number: 66204-44-2
Endpoint summary
Administrative data
Description of key information
There is evidence for a sensitizing activity of the substance and/or its hydrolysis products.
Additional information
Numerous formaldehyde releasers were tested in the study published by Geier et al. (1997). The substance has been shown to induce the highest frequency of contact allergy in the human. In a group of 1786 patients 55 patients (or 3.1%) showed a positive reaction after exposure to the substance. In this study 1406 patients were tested with Grotan®OX and additionally with formaldehyde. 46 out of 1406 showed a positive reaction with Grotan®OX and in 13 out of these 46 patients a positive reaction was also observed with formaldehyde. These data suggested that the formaldehyde releaser might induce sensitizing effects primarily via the whole reaction mixture and not only from released formaldehyde.
Further evidence for sensitizing activity in humans is presented by Schnuch et al. (1998) and Brinkmeier et al. (2002, small number of patients) reporting similar results.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
