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Diss Factsheets
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EC number: 231-212-3 | CAS number: 7447-41-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Read-across from other Lithium compounds does not allow the conclusion that Lithium chloride may cause developmental/ teratogenic or reproductive effects in humans.
Additional information
As Lithium has been used in psychiatric therapy for the treatment of bipolar disorder for decades and Lithium chloride is also reported as drug to treat bipolar disorder, but rarely used compared to Lithium carbonate, most observations in humans are related to Lithium carbonate. The toxicity is most likely triggered by Lithium and not by carbonate or chloride as
- chloride is the most abundant anion in humans and all animal species and an essential element of the human body being responsible for metabolism,
- carbonate occurs ubiquitous and represents a physiological molecule.
Therefore, read-across from these reports to Lithium chloride is applicable.
This also applies for Lithium compounds that were not specified in the reports as they were administered for therapeutic reasons and are not expected to have a toxic counter ion. The reports on observations in humans did not allow conclusions that Lithium, resectively Lithium chloride
- may cause developmental/ teratogenic effects in humans (This is further supported by a recently performed study with Lithium carbonate in rats according to OECD 414, revealing no indication for a teratogenic potential of the Lithium salt. )
- is responsible for Ebstein's anomaly
- may impair male fertility (except the libido may be reduced due to treatment by a psychotropic drug).
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