Registration Dossier
Registration Dossier
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EC number: 219-919-5 | CAS number: 2571-88-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See 2018_Read-across-Justification_V1 in attached justification
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
Test material
- Reference substance name:
- N,N-dimethyloctadecylamine N-oxide
- EC Number:
- 219-919-5
- EC Name:
- N,N-dimethyloctadecylamine N-oxide
- Cas Number:
- 2571-88-2
- Molecular formula:
- C20H43NO
- IUPAC Name:
- N,N-dimethyloctadecanamine oxide
Constituent 1
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 1 706 mg/kg bw
- Based on:
- other: Based on Amine Oxides
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- As indicated in the read-across justification, data from Amine oxide can be used for read-across to N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) acute oral toxicity.
Concerning the read-across approach, the data on the other C18 Amine Oxide (Dihydroxyethyl oleamine oxide - CAS 93962-62-0) was used to determine the LD50 of N,N-Dimethyl-1-octadecanamine-N-oxide :
- The LD50 female rat is 1 706 mg/kgbw
- The LD50 male rat is 7 489 mg/kgbw - Executive summary:
As indicated in the read-across justification, data from Amine oxide can be used for read-across to N,N-Dimethyl-1-octadecanamine-N-oxide (CAS 2571-88-2 / EINECS 219-919-5) acute oral toxicity.
Concerning the read-across approach, the data on the other C18 Amine Oxide (Dihydroxyethyl oleamine oxide - CAS 93962-62-0) was used to determine the LD50 of N,N-Dimethyl-1-octadecanamine-N-oxide :
- The LD50 female rat is 1 706 mg/kgbw
- The LD50 male rat is 7 489 mg/kgbw
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