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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1992
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Qualifier:
according to guideline
Guideline:
OECD Guideline 201 (Alga, Growth Inhibition Test)
Deviations:
yes
Remarks:
Individual cell counts not reported. Growth in controls not reported. pH not reported. Concentrations were probably stable, but may have decreased during this test.
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
not specified
Test organisms (species):
Pseudokirchneriella subcapitata (previous names: Raphidocelis subcapitata, Selenastrum capricornutum)
Test type:
not specified
Water media type:
not specified
Total exposure duration:
72 h
Hardness:
(Ca + Mg) dH 0.6 mmol/l
Test temperature:
20-22 oC
pH:
-
Dissolved oxygen:
-
Nominal and measured concentrations:
Nominal test concentrations 0.0 - 0.024 - 0.044 - 0.078 - 0.14 - 0.26 mg/l (active ingredient).
Details on test conditions:
TEST SYSTEM
- Initial cells density: 25,000 cells/ml
- Control end cells density: Cell density measurements at 0, 24, 48 and 72h (spectrophotometrically).
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 6
Reference substance (positive control):
not specified
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
ca. 0.06 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
biomass
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
ca. 0.1 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
biomass
Duration:
72 h
Dose descriptor:
EC20
Effect conc.:
ca. 0.07 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
biomass
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
ca. 0.14 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
EC20
Effect conc.:
ca. 0.1 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Duration:
72 h
Dose descriptor:
EC10
Effect conc.:
ca. 0.08 mg/L
Nominal / measured:
nominal
Conc. based on:
act. ingr.
Basis for effect:
growth rate
Validity criteria fulfilled:
yes
Conclusions:
According to OECD guideline 201, the EC50, 72h for Octadecanamine, N,N-dimethyl-, N-oxide (CAS No. 2571-88-2) is 0.14 mg/L.
Executive summary:

According to OECD guideline 201, the EC50, 72h for Octadecanamine, N,N-dimethyl-, N-oxide (CAS No. 2571-88-2)  is 0.14 mg/L.

Description of key information

According to OECD guideline 201, the EC50, 72h for Octadecanamine, N,N-dimethyl-, N-oxide (CAS No. 2571-88-2)  is 0.14 mg/L.

As indicated in the SIDS initial Assessment Report (SIAM 22, 2006), based on the hazard data of Amine Oxide data, the most sensitive freshwater species are green algae (Selenastrum and Scenedesmus). Therefore, this value is retained for the classification.

Key value for chemical safety assessment

EC50 for freshwater algae:
0.14 mg/L

Additional information