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EC number: 609-080-7 | CAS number: 35160-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Testing for sensitising properties of phosphinic acid, diethyl aluminium salt (source substance)
was performed in female guinea pigs according to OECD 406. Intradermal induction was performed using 5 %, the dermal induction using 25% in sesame oil. The challenge was carried out with 25% test substance (epidermal) sesame oil.
Phosphinic acid, diethyl aluminium salt (source substance) did not induce allergic reactions and therefore, phosphinic acid, diethyl sodium salt (target substance) is not considered to be a skin sensitiser.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- no
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- already existing in vivo data
- Species:
- guinea pig
- Strain:
- Pirbright-Hartley
- Sex:
- female
- Details on test animals and environmental conditions:
- according to guideline
- Route:
- intradermal
- Vehicle:
- other: sesame oil (DAB 10)
- Concentration / amount:
- intradermal: 5% in seame oil; dermal: 25% in sesame oil
- Day(s)/duration:
- 2
- Adequacy of induction:
- highest concentration used causing mild-to-moderate skin irritation and well-tolerated systemically
- Route:
- epicutaneous, occlusive
- Vehicle:
- other: sesame oil (DAB 10)
- Concentration / amount:
- dermal: 25% in seame oil
- Day(s)/duration:
- 1
- Adequacy of challenge:
- highest non-irritant concentration
- No. of animals per dose:
- test group: 10
controll group 5 - Details on study design:
- according to guideline
- Challenge controls:
- according to guideline
- Positive control substance(s):
- yes
- Remarks:
- The validity of the test system is confirmed by the periodically conducted positive control test using benzocain for the maximization test (report no. 97.0326, dated June 02, 1997).
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 25%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no signes
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- 25%
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- no signs
- Remarks on result:
- no indication of skin sensitisation
- Key result
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- no signs
- Key result
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- 0%
- No. with + reactions:
- 0
- Total no. in group:
- 5
- Clinical observations:
- no signs
- Interpretation of results:
- GHS criteria not met
- Remarks:
- no sensitising
- Conclusions:
- In a guinea pig sensitization study according to OECD 406 caused no allergic reaction in all animals. The number of affected guinea pigs was not high enough to be significant. Methylparaben is not considered to be a skin sensitiser. Therefore, the test substance has not to be classified as skin sensitiser.
- Executive summary:
Testing for sensitising properties of phosphinic acid, diethyl aluminium salt (source substance)
was performed in female guinea pigs according to OECD 406. Intradermal induction was performed using 5 %, the dermal induction using 25% in sesame oil. The challenge was carried out with 25% test substance (epidermal) sesame oil.
Phosphinic acid, diethyl aluminium salt (source substance) did not induce allergic reactions and therefore, phosphinic acid, diethyl sodium salt (target substance) is not considered to be a skin sensitiser.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Testing for sensitising properties of phosphinic acid, diethyl aluminium salt (source substance)
was performed in female guinea pigs according to OECD 406. Intradermal induction was performed using 5 %, the dermal induction using 25% in sesame oil. The challenge was carried out with 25% test substance (epidermal) sesame oil.
Phosphinic acid, diethyl aluminium salt (source substance) did not induce allergic reactions and therefore, phosphinic acid, diethyl sodium salt (target substance) is not considered to be a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
There are no respiratory sensitization properties of the substance known in literature. Beyond this there is no hint of any sensitization property of the compound (source substance) from the conducted skin sensitization study. Therefore, it is concluded that the substance is not a respiratory sensitizer.
Justification for classification or non-classification
The source substance (phosphinic acid, diethyl, aluminium salt has been tested to the Guinea pig maximization test according to OECD 406 to assess the sensitising potential of the test item. The study did not result in a allergical response.
A classification concerning skin and respiratory sensitizing properties is not warranted for the target substance phosphinic acid, diethyl, sodium salt as the classification criteria according to EU regulation 1272/2008 are not met.
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