Registration Dossier
Registration Dossier
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EC number: 483-300-8 | CAS number: 99580-93-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 2007-11-26 till 2007-12-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline-conform study under GLP without deviations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 92/69/EWG, B.3
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 483-300-8
- EC Name:
- -
- Cas Number:
- 99580-93-5
- Molecular formula:
- Hill formula: C3H13N2O3P CAS formula: C2H8N2.CH5O3P
- IUPAC Name:
- 1,2-Ethanediamine methylphosphonate
- Test material form:
- solid: bulk
- Details on test material:
- Batch number: FEB 278-810
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Species/strain:
rat, Wistar Hsd:HanRcc (SPF)
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- other: aqua ad inject
- Duration of exposure:
- 24 h
- No. of animals per sex per dose:
- 5 males/ 5 females
- Control animals:
- no
- Statistics:
- not necessary
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels:
No treatment related effects observed. - Body weight:
- see Table 1
- Gross pathology:
- Effects on organs:
No treatment related effects observed. - Other findings:
- Signs of toxicity (local):
No treatment related effects observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item has no acute dermal toxic characteristics. The dermal LD50 was determined to be > 2000 mg/kg bw.
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