Registration Dossier
Registration Dossier
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EC number: 232-178-2 | CAS number: 7789-60-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Initial Submission: Acute Oral Toxicity of Phosphorous Tribromide in Rats with Cover Letter Dated 08126/92
- Author:
- Eastman Kodak Co
- Year:
- 1 992
- Bibliographic source:
- OTS0555394, Eastman Kodak Company, 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of phosphorus (3+) tribromide in rats
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorus tribromide
- EC Number:
- 232-178-2
- EC Name:
- Phosphorus tribromide
- Cas Number:
- 7789-60-8
- Molecular formula:
- Br3P
- IUPAC Name:
- phosphorus tribromide
- Test material form:
- liquid
- Details on test material:
- - Name of test material : Phosphorus tribromide
- Molecular formula: Br3P
- Molecular weight : 270.686 g/mol
- Smiles notation :P(Br)(Br)Br
- InChl :1S/Br3P/c14(2)3
- Substance type: Inorganic
- Physical state: Solid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material : Phosphorus tribromide (phosphorus (3+) tribromide)
- Molecular formula: Br3P
- Molecular weight : 270.686 g/mole
- Smiles notation :P(Br)(Br)Br
- InChl :1S/Br3P/c14(2)3
- Substance type: Inorganic
- Physical state: Solid
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- not specified
- Doses:
- 50,400 and 3200 mg/kg bw
- No. of animals per sex per dose:
- 3
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs and body weight were examined. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- < 50 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: More than 50 % mortality was observed
- Mortality:
- More than 50 % mortality was observed in treated rats at 50 mg/kg bw within 2 min-1 day after dosing
- Clinical signs:
- other: Weakness, prostration (wet around mouth, difficult breathing) were observed.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- LD50 was considered to be < 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.
- Executive summary:
In a acute oral toxicity study, rat were treated with phosphorus (3+) tribromide in the concentration of 50,400 and 3200 mg/kg bw orally. 50 % mortality was observed in treated rats at 50 mg/kg bw within 2 min-1 day after dosing. Weakness, prostration (wet around mouth, difficult breathing) were observed. Therefore,LD50 was considered to be< 50 mg/kg bw when rat were treated with phosphorus (3+) tribromide orally.
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