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EC number: 215-958-7 | CAS number: 1461-22-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- nda
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: No GLP or purity info. Similar to OECD 403 but with severe deviations. Used as supporting study only due to restrictions. Only 2 concentrations used. LC50 is a less than value due to deaths.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Principles of method if other than guideline:
- Used as supporting study only due to restrictions.
- Only 2 concentrations used.
- LC50 is a less than value due to deaths. - GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tributyltin chloride
- EC Number:
- 215-958-7
- EC Name:
- Tributyltin chloride
- Cas Number:
- 1461-22-9
- Molecular formula:
- C12H27ClSn
- IUPAC Name:
- tributylstannanylium chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Tif: RAI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The test was performed on 36 Tif. RAI rats (18 males/18 females), bred under SPF conditions in our own breeding unit. The animals used were 7 to 8 weeks old and weighed between 170 and 185 g. The males and females were segregated and kept in Macrolon cages, type 4, (9 animals to a cage) during an observation period of 7 days in a room maintained at a constant temperature of 22 ± 1 °C and a relative humidity of approximately 50 %.
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- obtained gravimetrically
- Duration of exposure:
- 4 h
- Concentrations:
- 78 & 403 mg/m^3.
- No. of animals per sex per dose:
- 18 males and 18 females
- Control animals:
- not specified
- Details on study design:
- The test material was tested for acute inhalation toxicity by the exposure of albino rats to an aerosol generated from this product. The test material was sprayed into the exposure chamber by means of a pressure nozzle. The liquid was injected by a motor-driven syringe at a rate of 0.6 and 3 mL/hr into a stream of compressed air (2 atm.) flowing through a spray nozzle at a rate of 10 L/min. The aerosol mist thus produced was discharged into the exposure chamber.
The test animals were kept in separate PVC tubes positioned radially around the exposure chamber. These tubes were so designed that only the animals snouts were exposed to the aerosol. The animals were not exposed until the aerosol was evenly dispersed throughout the chamber (15 minutes). The exposure time was four hours. The aerosol was sampled on Membrane Filters, pore size 0.2 µm (Satorius, 34 Göttingen, Germany) in the immediate vicinity of the animals hourly after the beginning of the test. The individual concentrations of the test material were determined gravimetrically.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- < 78 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Clinical signs:
- other: After the 4 hour exposure all animals showed dyspnoea, exophthalmos, lateral position, cyanosis and apathy.
- Gross pathology:
- Autopsy of dead animals: haemorrhages in the lungs and congested organs were seen.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- The LC50 of the test material was determined after an observation period of 7 days in rats of both sexes, exposed to the test material for four hours is smaller than 78 mg/m^3, air.
- Executive summary:
The LC50 of the test material was determined after an observation period of 7 days in rats of both sexes, exposed to the test material for four hours is smaller than 78 mg/m^3, air.
According to the classification proposed by Sachsse et al. (1974) the test material has a high acute toxicity to the rat by this route of administration.
After the 4 hour exposure all animals showed dyspnoea, exophthalmos, lateral position, cyanosis and apathy. In the autopsy of dead animals, haemorrhages in the lungs and congested organs were seen.
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