Benzoyl chloride

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

sub-chronic toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

publication

Title:

Über das Auftreten von Krebs bei Mäusen nach Inhalation von Benzotrichlorid und Benzoylchlorid

Author:

Yoshimura H., Takemoto K.; Fukuda K. and Matsushita H.

Year:

1986

Bibliographic source:

Japanese Journal of Industrial health, 28: 352-359

Materials and methods

Principles of method if other than guideline:

Carcinogenicity induced by repeated inhalation
(For details on methodology see section examinations)

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Benzoyl chloride

EC Number:

202-710-8

EC Name:

Benzoyl chloride

Cas Number:

98-88-4

Molecular formula:

C7H5ClO

IUPAC Name:

benzoyl chloride

Test material form:

liquid

Test animals

Species:

mouse

Strain:

ICR

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Analytical verification of doses or concentrations:

yes

Duration of treatment / exposure:

5 months

Frequency of treatment:

twice weekly for 30 minutes

No. of animals per sex per dose:

30 (28 were evaluated)

Control animals:

yes

Results and discussion

Results of examinations

Clinical signs:

not specified

Mortality:

not specified

Body weight and weight changes:

not specified

Effect levels

Dose descriptor:

other: No available

Basis for effect level:

other:

Remarks on result:

other: Not available

Target system / organ toxicity

Critical effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

The authors tested the toxicity of benzoyl chloride after repeated dose exposure via inhalation of vaporized test substance. Only cutaneous lesions were observed, no pulmonary. The gross pathology of animals showed inflammation of the lymp nodes, liver and spleen. Also mild keratosis and hyperplasia of the gastric mucosa was seen. On the other hand no malignant lymphoma were noted.

Executive summary:

The authors tested the toxicity of benzoyl chloride (CAS n° 98-88-4)after repeated dose exposure via inhalation of vaporized test substance. Thirty ICR male mice were exposed to benzoyl chloride vaporized at 50°C twice weekly for 30 minutes during 5 months. Afterwards they were observed for another 9 months. Pathological changes in the respiratory system and skin were noted as well as mortality and gross pathology.

At the end of exposure hair-loss and inflammation was observed. At necropsy, many animals showed inflammation of the lymp nodes, liver and spleen. Also mild keratosis and hyperplasia of the gastric mucosa was seen. Finally no malignant lymphoma were noted.

 

The GLP status of the study is unknown. Although the study would benefit from a more elaborate description of clinical signs, gross pathology and weight development, it is nevertheless sufficiently documented, meets generally accepted scientific principles and is acceptable for assessment. Thus the study is reliable with restrictions, Klimisch 2e.