Registration Dossier
Registration Dossier
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EC number: 417-220-1 | CAS number: 37441-29-5 ATIPACL
Endpoint summary
Administrative data
Description of key information
NOAEL (oral, rat, 28 days) = 1000 mg/kg bw/day
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Repeated Dose Toxxxicity: Oral
The test substance was evaluated for toxicological effects in male and female Wistar strain WI rats accoridng to EU method B7 following oral dietary administration at levels of 50, 200 and 1000 mg/kg/day seven days a week for 28 days. The examination included: clinical signs, mortality, body weight and weight changes, behaviour, clinical laboratory analysis (hematology, urinalysis) and gross pathology.No mortality was observed. No clinical signs of toxicity or behavioural changes over the 28d observation period that were related to treatment were observed. Incidental findings were within the normal biological variation of result of oral administration and the taste of the test substance.
The NOAEL for this study is 1000 mg/kg bw/day (nominal).
Justification for classification or non-classification
Considering the avalaiable results from the 28 -days repeated dose toxicity study and the NOAEL determined, the substance is not classified for Specific Target Organ Toxicity - Repeated Exposure (STOT-RE) according to the CLP Regulation EC No. 1272/2008
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