Registration Dossier
Registration Dossier
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EC number: 417-220-1 | CAS number: 37441-29-5 ATIPACL
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 994
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 5-amino-2,4,6-triiodo-1,3-benzenedicarbonyldichloride
- EC Number:
- 417-220-1
- EC Name:
- 5-amino-2,4,6-triiodo-1,3-benzenedicarbonyldichloride
- Cas Number:
- 37441-29-5
- Molecular formula:
- C8H2Cl2I3NO2
- IUPAC Name:
- 5-amino-2,4,6-triiodobenzene-1,3-dicarbonyl dichloride
- Test material form:
- solid: particulate/powder
- Remarks:
- powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact skin
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- 0,5g prepared as a paste with 0,21g of water
- Duration of treatment / exposure:
- 4h
- Observation period:
- 24, 48 and 72h
- Number of animals:
- 6 males
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
- Remarks on result:
- other: erythema mean for each animal not available. max score 4 was observed after 1h
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 4
- Remarks on result:
- other: edema mean for each animal not available
- Irritant / corrosive response data:
- from the results obtained under the experimental conditions employed, application of this test article to the rabbit skin did not provoke any noticeable irritation.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified for skin irritation according to CLP Regulation (EC) 1272/2008.
- Conclusions:
- From the results obtained under the experimental conditions employed, application of this test article to the rabbit skin did not provoke any noticeable irritation.
- Executive summary:
The skin irritation potential of the test substance was evaluated in an in vivostudy in accordance with the OECD guideline No. 404, 'Acute Dermal Irritation/Corrosion'.
The test substance was applied in six New Zealand White rabbits at the intact skin. The observation period was 24, 48 and 72 hours after the start of application.
Irritation score was 0 for all rabbits.
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