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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Described in SNIF 05-04-1850-00 lead notification under NONS. Originaly reports not read.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2005

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
Deviations:
no
GLP compliance:
not specified
Remarks:
Original reports not seen
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
454-720-9
EC Name:
-
Cas Number:
161596-47-0
Molecular formula:
C11 H9 N O3
IUPAC Name:
2-{[(2R)-oxiran-2-yl]methyl}-2,3-dihydro-1H-isoindole-1,3-dione

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: drinking water
Vehicle:
other: 2% Cremophor EL
Doses:
2000mg/kg
No. of animals per sex per dose:
3

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Original reports not seen

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information LD50>2000mg/kg Criteria used for interpretation of results: EU
Conclusions:
The material is not classefied.
Executive summary:

The material is not classefied.