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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets national standard methods with acceptable restrictions
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Referenceopen allclose all

Reference Type:
other company data
Title:
Unnamed
Year:
1974
Report date:
1974
Reference Type:
secondary source
Title:
No information
Author:
BASF AG
Year:
2008
Bibliographic source:
RIFM database

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Principles of method if other than guideline:
Study was performed acc. internal BASF method, which was in large part equivalent to OECD 403
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
6-methylhept-5-en-2-one
EC Number:
203-816-7
EC Name:
6-methylhept-5-en-2-one
Cas Number:
110-93-0
IUPAC Name:
6-methylhept-5-en-2-one
Details on test material:
- Name of test material (as cited in study report): 6-Methyl-5-hepten-2-one
- Analytical purity: 98 %

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: average 167 g

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
whole body
Vehicle:
other: air
Details on inhalation exposure:
GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- System of generating particulates/aerosols: generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted glass disc in a glass cylinder for different time periods (8 hours)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
Concentrations:
6.98 mg/l (6980 mg/m3) was calculated by using the weight loss of test substance and the amount of air used during exposure.
No. of animals per sex per dose:
12 animals were used
Control animals:
no
Details on study design:
- Duration of observation period following administration: 7 days
- Frequency of weighing: before the start of the study and at the end of the observation period in the surviving animals
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levelsopen allclose all
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 6.98 mg/L air
Exp. duration:
8 h
Sex:
male/female
Dose descriptor:
LC50
Effect level:
> 13.96 mg/L air
Exp. duration:
4 h
Remarks on result:
other: acc. Haber's law
Clinical signs:
other: Immediately after exposure, the animals showed impaired balance. The next day, all animals were normal again.
Gross pathology:
no abnormal effects detected

Any other information on results incl. tables

A LC50 of > 13.96 mg/l/4 hrs (> 13,960 mg/m3/4hrs) could be estimated  using Haber's rule, LC50 > 6.98 mg/l/8 hrs (> 6,980 mg/m3/8 hrs).

Applicant's summary and conclusion

Interpretation of results:
practically nontoxic
Remarks:
Migrated information Criteria used for interpretation of results: EU