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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

Toxicity to microorganisms

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Description of key information

EL50 (48h) = 48.39 mg/L (QSAR, read-across from hexane and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane)
NOELR (48h) = 10.82 mg/L (QSAR, read-across from hexane)

Key value for chemical safety assessment

Additional information

There are no data available on the toxicity to microorganisms of hydrocarbons, C5-C6, n-alkanes, isoalkanes, <5% n-hexane. However, there are reliable data available considered suitable for read-across using the analogue approach.

The target substance is a hydrocarbon solvent with carbon numbers in the range of C5 to C6. The main constituents of the mixed solvent consist of about 43% of C6 species and about 57% of C5 species. n-Hexane is only present in concentrations < 5% of the total volume.

Taking into account all available data, animal and human toxicity data as well as environmental fate and effects data show that source substances have a similar (eco-)toxicological and environmental fate properties as the target substance.

Therefore, read-across is performed based on an analogue approach (for details please refer to the analogue justification which is attached in section 13 of the technical dossier).

For a number of analogue substances the aquatic toxicity was estimated by a QSAR, using the Petrotox computer model (v 3.04), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of non-polar narcotic chemicals. Petrotox computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partition coefficients K(MW) that describe the partitioning of the hydrocarbons between the water and organism. The estimated freshwater 48 hour EL50 and NOELR values based on growth inhibition are as follows:

Hydrocarbons, C6, isoalkanes, < 5% n-hexane: EL50 = 70.68 mg/L (Concawe 2009)

Hydrocarbons, C6, isoalkanes, < 5% n-hexane: NOELR = 15.81 mg/L (Concawe 2009)

Hexane: EL50 = 48.39 mg/L (Concawe 2009)

Hexane: NOELR = 10.82 mg/L (Concawe 2009)

Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich: EL50 = 51.84 mg/L (Concawe 2009) Hydrocarbons, C5-C7, n-alkanes, isoalkanes, n-hexane rich: NOELR = 11.59 mg/L (Concawe 2009)

Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich: EL50 = 48.39 mg/L (Concawe 2009)

Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich: NOELR = 11.54 mg/L (Concawe 2009)

Pentane: EL50 = 105.9 mg/L (Concawe 2009) Pentane: NOELR = 23.7 mg/L (Concawe 2009)

QSARs resulted in EL50s and NOELRs in a range of 48.39 mg/L - 105.9 mg/L and 10.82 mg/L - 23.7 mg/L, respectively. As key studies the QSARs conducted for hexane and Hydrocarbons, C6, n-alkanes, isoalkanes, cyclics, n-hexane rich were chosen demonstrating the most critical EL50 with 48.39 mg/L and NOELR with 10.82 mg/L.