Registration Dossier
Registration Dossier
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EC number: 203-309-0 | CAS number: 105-56-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP LAB testing
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
Test material
- Reference substance name:
- Ethyl cyanoacetate
- EC Number:
- 203-309-0
- EC Name:
- Ethyl cyanoacetate
- Cas Number:
- 105-56-6
- Molecular formula:
- C5H7NO2
- IUPAC Name:
- ethyl 2-cyanoacetate
- Test material form:
- other: colorless liquid
- Details on test material:
- Tank 434 colorless liquid 99.7%(GC-analysis), water content of 0.02%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- at start: Six to eight week old animals.
Housing: conventionel, separated by sex maxium 5 animals
room temperature: 20±3℃
Humidity: 30-70%
artificial light: 12 hours dark cycle
Diet:3 hours post application ad libitum fed group
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- The application volume was 1.89 cm3/kg bw
- Doses:
- 2000mg/kg bw
- No. of animals per sex per dose:
- 5 males/5 females
- Control animals:
- not specified
- Details on study design:
- Observation period: 14days
The animals were 1/2,1,2,3,4,5 and 6 hours after application and examined in the following two weeks once daily for clinical symptoms.
Results and discussion
- Preliminary study:
- A limited test carried out by number of animals of the preliminary study was expanded with three male and three females with 2000 mg/kg bw dose.
The animals of the pre-test was not reported individually in the results, but summarized with animals of the limit test
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality was observed
- Clinical signs:
- other: At a dose of 2000mg/kg bw, the animals showed poisoning symptoms after 2-6 hours administration. While all animals had a ruffled fur, some animals showed abnomal passage, abdominal/ side position, sedation or ataxia, reduced motility, tremor, increased re
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
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