Registration Dossier
Registration Dossier
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EC number: 201-178-4 | CAS number: 79-11-8
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- other: Risk Asssessment Report
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 2 (reliable with restrictions)
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Reference Type:
- other: Risk Assessment Report
- Title:
- Monochloro acetic acid - Summary risk assessment report
- Author:
- Institute for Health and Consumer Protection European Chemicals Bureau
- Year:
- 2 005
- Bibliographic source:
- I-21020 Ispra (VA) Italy - Monochloro acetic acid - Summary risk assessment report
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: umu test
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Chloroacetic acid
- EC Number:
- 201-178-4
- EC Name:
- Chloroacetic acid
- Cas Number:
- 79-11-8
- Molecular formula:
- C2H3ClO2
- IUPAC Name:
- chloroacetic acid
- Test material form:
- solid: crystalline
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535 pSK1002
- Test concentrations with justification for top dose:
- 330 ug/mL
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 1535 pSK1002
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Remarks on result:
- other: other: Test with and without metabolic activation with S-9. NEF
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Choloroacetic acid gave negative results for mutagenicity with and without metabolic activation - Executive summary:
Choloroacetic acid gave negative results for mutagenicity with and without metabolic activation
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