Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
3 (not reliable)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1977
Report date:
1977

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Methyl chloroformate
EC Number:
201-187-3
EC Name:
Methyl chloroformate
Cas Number:
79-22-1
Molecular formula:
C2H3ClO2
IUPAC Name:
methyl chloroformate

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
shaved
Vehicle:
other: paraffin oil
Controls:
not required
Amount / concentration applied:
0.5 g
Duration of treatment / exposure:
4 h
Observation period:
24 h, 48 h, 14 d

Results and discussion

In vivo

Results
Remarks on result:
other: 24 hours after exposure a green colouring of skin around a point of application occurs. After 48 hours the whole depilated place was green with edema.
Irritant / corrosive response data:
24 hours after exposure a green colouring of skin around a point of application occurs. After 48 hours the whole depilated place was green with edema.

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU