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Diss Factsheets
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EC number: 403-960-2 | CAS number: 126877-05-2 C.I. DISPERSE RED 367
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: see attached file
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2-ethoxyethyl-2-(4-(2,6-dihydro-2,6-dioxo-7-phenyl-1,5-dioxaindacen-3-yl)phenoxy)acetate
- EC Number:
- 403-960-2
- EC Name:
- 2-ethoxyethyl-2-(4-(2,6-dihydro-2,6-dioxo-7-phenyl-1,5-dioxaindacen-3-yl)phenoxy)acetate
- Cas Number:
- 126877-05-2
- Molecular formula:
- C28H22O8
- IUPAC Name:
- 2-ethoxyethyl 2-(4-{5,11-dioxo-12-phenyl-4,10-dioxatricyclo[7.3.0.0³,⁷]dodeca-1(12),2,6,8-tetraen-6-yl}phenoxy)acetate
- Details on test material:
- - Sample reference: NBW 8809/52
- CTL reference number Y04203/002/001
- Physical state: red powder
- Supplier : ICI Colours and Fine Chemicals, Blackley, Manchester
- moisture content : 0.2 % water
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Mellor Rabbits, Chadderton Heights, Chadderton, Nr Oldham, Greater Manchester, UK.
- Age at study initiation: young adult
- Weight at study initiation: 3707, 4331 and 4381g.
- Housing: satinised aluminium sheet cages (60.5cm width x 49cm depth x 45.5cm height), floor of each cage made of perforated aluminium sheet and, door made of polycarbonate (MAKROLON).
Test system
- Observation period (in vivo):
- 1-2 hours, 1, 2, 3, 4 and 7 days after application.
- Number of animals or in vitro replicates:
- 3 females
Results and discussion
Any other information on results incl. tables
Application of the test sample into the eye caused a slight initial pain reaction (class 2 on a 0-5 scale) in all three rabbits. Immediately
following application, approximately one third of the test sample was di spl aced from the conjunctival sac of two rabbits and approximately one quarter was displaced from the conjunctival sac of the remaining rabbit.
There were no corneal or iridial effects in any animal. Conjunctival irritation, including redness, chemosis and discharge, was observed in all three animals and persisted for up to four days after application, in two animals. All signs of irritation had disappeared seven days after application.
Additional observations made during the study were red staining of the periorbital area of the eye by the test substance (two animals). In addition, one animal had convoluted eyelids. All additional signs of irritation had disappeared by Day 7.
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: modified form of the Kay and Calandra system
- Conclusions:
- In conclusion, substance was classed as a mild irritant (class 4 on a 1-8 scale based on a modified form of the Kay and Calandra system) to the rabbit eye.
- Executive summary:
mild irritant
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