2,4,6-tri-sec-butylphenol

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 404 (Acute Dermal Irritation / Corrosion)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,4,6-tri-sec-butylphenol

EC Number:

227-572-6

EC Name:

2,4,6-tri-sec-butylphenol

Cas Number:

5892-47-7

Molecular formula:

C18H30O

IUPAC Name:

2,4,6-tris(butan-2-yl)phenol

Test material form:

liquid

Details on test material:

Product-Nr. /Code: GTGD 155

Test animals

Species:

rabbit

Strain:

New Zealand White

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

unchanged (no vehicle)

Duration of treatment / exposure:

Single application

Observation period:

14 days

Number of animals:

3

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Basis:

animal: observations in three animals

Time point:

24/48/72 h

Score:

1.67

Max. score:

3

Reversibility:

fully reversible within: 14 days

Remarks on result:

positive indication of irritation

Results 2

Irritation parameter:

edema score

Basis:

animal: observations in three animals

Time point:

24/48/72 h

Score:

0.57

Max. score:

2

Reversibility:

fully reversible within: 7 days

Remarks on result:

positive indication of irritation

Any other information on results incl. tables

Table: Skin irritation scores
Observation Time	Erythema			Oedema
	Animal 1	Animal 2	Animal 3	Animal 1	Animal 2	Animal 3
1h	2	0	1	1	0	1
24h	2	2	1	0	1	1
48h	2	2	0	0	1	0
72h	3	3	0	2	0	0
7 day	4	2	-	0	0	-
14 day	0	0	-	0	0	-
Mean of 24/48/72h	2.3	2.3	0.3	0.7	0.7	0.3

Table: Observations of treated area
Observation Time	Animal 1			Animal 2			Animal 3
	Discoloration	Dry/ Rough/ Chapped	Scaling/ Desquamation/ New skin	Discoloration	Dry/ Rough/ Chapped	Scaling/ Desquamation/ New skin	Discoloration	Dry/ Rough/ Chapped	Scaling/ Desquamation/ New skin
1h
2 day					x
3 day					x
7 day		x	x	x	x	x
14 day			x		x

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

The registration substance was investigated for its skin irritaiton property according to OECD 404. It was found to be irritating to skin.

Executive summary:

The registration substance was investigated for its skin irritaiton property according to OECD 404.

Among the three rabbits treated, two rabbits exhibited erythema of mean score of 2.3 for 24,48, and 72 hours reading and exhibited discoloration, dryness and scaling at reading time 7 and 14 day. The registration substance was found to be irritating to skin.