Hydrocarbons, C15-C19, n-alkanes, isoalkanes,

Endpoint summary

Description of key information

For short and long-term toxicity to fish, there is no data available for this substance. However, key, weight-of-evidence and supporting data is available for structural analogues. The data is read across to this substance based on analogue read across and a discussion and report on the read across strategy is provided as an attachment in IUCLID Section 13.

Measured or estimated data for short-term toxicity to aquatic invertebrates; long-term toxicity to aquatic invertebrates; toxicity to algae and cyanobacteria; and toxicity to microorganisms are available for the registered substance.

The substances are poorly soluble and made of constituents with various water solubility. As a consequence, the exposures were performed with Water Accommodated Fractions (WAFs). Therefore, the results are based on nominal loadings. The toxicity level was never reached in any fish study despite the high loading level tested. Therefore, this substance is considered to display no acute aquatic toxicity based on an analogue read across approach.

For the chronic effects, very long term exposure to 1% pristane, 1% dodecylcyclohexane or 1% n-alkanes in diet reduces fish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects are reversible. Long-term -toxicity to aquatic invertebrates was predicted by a PETROTOX computer model. An estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value of >1000 mg/l based on reproduction of Daphnia magna was determined

Additional information

Key data is summarised below:

For short and long-term toxicity to fish, there is no data available for this substance. However, key, weight-of-evidence and supporting data is available for structural analogues.

Short-term toxicity to fish:

Hydrocarbons, C14-C18, n-alkanes, isoalkanes, cyclics, <2% aromatics presented a 96-h LL50 (mortality) for juveniles of the marine fish Scophthalmus maximus of > 1028 mg/L (based on nominal loading rate).

The toxicity level was never reached in any study despite the high loading level tested. Therefore, this substance is considered to display no acute toxicity to fish based on an analogue read across approach.

Long-term toxicity to fish:

1% pristane, 1%dodecylcyclohexane or 1% n-alkanes long-term exposures in fish diet reducedfish appetite, fish growth, lipid digestibility and canthaxanthin fixation in rainbow trout. The effects were reversible.No NOELR or NOEC value has been determined for long-term toxicity to fish.

Measured or estimated data for invertebrates and algae are available for the registered substance.

Short-term toxicity to aquatic invertebrates:

A 48 hour EL₅₀value of >100 mg/l and NOELR value of ≥100 mg/l (WAF loading rate) (highest concentration tested) have been determined for the effects of the test substance on mortality of Daphnia magna.

Long-term toxicity to aquatic invertebrates:

The Hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics, estimated freshwater invertebrate 21-day NOELR (No Observed Effect Loading Rate) value is >1000 mg/l based on reproduction.

Toxicity to aquatic algae and cyanobacteria:

A 72 hour EL₅₀ value of >100 mg/l and NOELR value of ≥100 mg/l (WAF loading rate) (highest concentration tested) have been determined for the effects of the test substance on growth rate of Pseudokirchneriella subcapitata.

Toxicity to microorganisms:

The Hydrocarbons, C15-C19, n-alkanes, isoalkanes, <2% aromatics, estimated protozoan,Tetrahymena elliotti, 48-hr EL₅₀value is >1000 mg/L based on growth inhibition.