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Diss Factsheets
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EC number: 219-323-5 | CAS number: 2414-98-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1994
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- This appears to be a well-run study evaluating a broad range of air concentrations in relation to the MAK value prevailing at the time. It is not clear from the original paper and its translation whether the blood alcohol levels expressed as 'promille' are mg/l or parts per million, former most likely, although this does not materially affect the conclusions.
Data source
Reference
- Reference Type:
- publication
- Title:
- Biomonitoring, Performance and Well-Being under Exposure to Inhalation of Ethanol.
- Author:
- Seeber, A., Blaszkewicz, M., Kiesswetter, E., Bandel, T., Golka, K., Heitmann, P., Vangala, R.R., Bolt, H.M.
- Year:
- 1 994
- Bibliographic source:
- Transact German Soc Occup & Environ Med. 34th Ann Meet, Weisbaden, 1994
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Human volunteer study examining blood ethanol concentrations resulting from differing inhalation exposures to ethanol vapour.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethanol
- EC Number:
- 200-578-6
- EC Name:
- Ethanol
- Cas Number:
- 64-17-5
- Molecular formula:
- C2H6O
- IUPAC Name:
- ethanol
- Details on test material:
- - No further data
Constituent 1
Test animals
- Species:
- human
- Strain:
- other: Assumed Caucasion
- Sex:
- male/female
Administration / exposure
- Route of administration:
- inhalation
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- 4 hour(s)
Doses / concentrations
- Remarks:
- Doses / Concentrations:
Males: 150 mg/cu m; 750 mg/cu m and 1500 mg/cu m; and exceeding MAK Females: 150 mg/cu m; 750 mg/cu m and 1500 mg/cu m and exceeding MAK
- No. of animals per sex per dose / concentration:
- Males: 12 Females: 12
- Control animals:
- no
- Statistics:
- Statistical tests included analysis of variance, F-test and correlation coefficients.
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- See remarks on results below.
- Details on distribution in tissues:
- not examined
- Details on excretion:
- not examined
Metabolite characterisation studies
- Metabolites identified:
- not measured
Any other information on results incl. tables
Blood alcohol levels were between 0.00023 and 0.0021 mg/ml in the first series and 0.00066 and 0.0056 mg/ml in the second (Units of concentration not clear in results). There was a very good correlation between inhalation exposure concentrations and resultant blood ethanol concentrations.
In both experiments there were no significant exposure-related effects in the psychological performance variables in both men and women. In the second experiments where concentrations varied about the MAK there were no significant effects at and below the MAK but at concentrations above the MAK (1000ppm), exposure was 'troublesome' (interpreted as caused discomfort to the volunteers).
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
- Executive summary:
In a human volunteer study using 24 men and women, it was established that exposures of up to 2000ppm of ethanol for periods of up to 4 hours do not saturate metabolism and that elimination kinetics are first order. A linear relationship was established between exposure concentration and resultant blood ethanol concentrations, leading to the prediction that the a maximum blood ethanol concentration of 2.9mg/l results from an (indefinite) exposure to 1000ppm of ethanol.
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