Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 207-975-3 | CAS number: 503-74-2
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature (peer review))
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
- Principles of method if other than guideline:
- Review article. Results from in vivo and in vitro investigations of adsorption, distribution, metabolism, and excretion of saturated banched-chain acyclic aliphatic alcohols, aldehydes and carboxylic acids are summarized.
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutyric acid
- EC Number:
- 201-195-7
- EC Name:
- Isobutyric acid
- Cas Number:
- 79-31-2
- IUPAC Name:
- 2-methylpropanoic acid
Constituent 1
Test animals
- Species:
- other: diferent species
Administration / exposure
- Route of administration:
- other: different routes of administration
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- rapid from GI tract
- Type:
- distribution
- Results:
- rapid elimination from blood after iv injection into mice
- Type:
- metabolism
- Results:
- mainly in liver to 3-HMG, acetoacetate, and acetyl-CoA
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Isobutyric acid does physiologically occur in the intermediary metabolism. It is rapidly absorbed from the GI tract and metabolised. - Executive summary:
Isobutyric acid does physiologically occur in the intermediary metabolism. It is rapidly absorbed from the GI tract and metabolised. Hence there is no bioaccumulation potential (Semino, 1998).
Isobutyric and isovaleric acid are both formed in the mammalian amino acid intermediary metabolism, and both are metabolised via similar pathways. Therefore, read across can be made between these acids though the degradation of isobutyric acid may proceed faster compared to isovaleric acid.
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