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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982

Materials and methods

Principles of method if other than guideline:
Oral gavage of 500 - 10000 mg/kg Versatic 6 to 4 rats per sex.
GLP compliance:
no
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-dimethylbutyric acid
EC Number:
209-865-0
EC Name:
2,2-dimethylbutyric acid
Cas Number:
595-37-9
Molecular formula:
C6H12O2
IUPAC Name:
2,2-dimethylbutanoic acid

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
500 - 1000 mg/kg
No. of animals per sex per dose:
4

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 790 - < 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion