Registration Dossier
Registration Dossier
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EC number: 294-785-9 | CAS number: 91770-03-5
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 06-12-2011 to 18-01-2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other:
- Radiolabelling:
- no
- Test temperature:
- 30°C
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Agilent Technologies 1100
- Type, material and dimension of analytical (guard) column: Luna 5µ CN 100Å (150 x 4.6 mm id), flow rate: 1.0 mL/min
- Detection system: UV detection (210 nm)
MOBILE PHASES
- Type: Methanol:water (55:45 v/v)
- pH: 6.8 adjusted with 0.1M sodium hydroxide
- Solutes for dissolving test and reference substances: methanol
DETERMINATION OF DEAD TIME
- Method: measurement of retention time of formaide (purity 99.94%, 688 mg/L solution in mobile phase)
REFERENCE SUBSTANCES
- Identity: See Appendix I attached.
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 0.9733 g in 100 mL, injection volume: 10µL
- Quantity of reference substances: See Appendix I attached.
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': using equation k = tr - t0 / t0 and Log Koc where
k = capacity factor
tr = retention time (min)
t0 = dead time (min)
- Calculation of retention times: calibration curve constructed from retention time data of deadtime and reference standard solutions
- Determination of the log Koc value: Log10 Koc = Log10 k-A / B where:
Koc = adsorption coeffcient
k = capacity factor
A = intercept of the calibration curve
B = slope of calibration curve. - Type:
- log Koc
- Value:
- > 5.63 dimensionless
- pH:
- 6.8
- Temp.:
- 30 °C
- Remarks on result:
- other: % organic carbon not determined for HPLC method
- Details on results (HPLC method):
- See Appendix 4: calibration curve and Appendix 5: retention times and Koc derivation (attached).
The test was performed at neutral pH as the test item contained no dissociation constants within the environmental pH range or scope of the test.
It was observed that the sample chromatography contained 3 peaks between 5 and 10 minutes. These were investigated by immediately injecting a sample after preparation at 10 g/L in methanol using the same method parameters. The chromatogram of the fresh sample showed no evidence of the initial 3 peaks and had a greater peak height for a corresponding concentration therefore confirming that test item degrades in a relatively short period of time in methanol. The definitive test result was taken just from the peaks eluted by the methanol gradient. - Validity criteria fulfilled:
- yes
- Conclusions:
- The absorption coefficient of the test item has been determined to be > 4.27 x 10E+05, Log Koc ≥ 5.63.
- Executive summary:
Test Guidance
OECD Guideline No. 121 and EC Method C19
Method and material
The determination was carried out using the HPLC screening method.
Results
The absorption coefficient of the test item has been determined to be > 4.27 x 10E+05, Log Koc ≥ 5.63.
Conclusion
The test substance has low mobility in soil.
- Endpoint:
- adsorption / desorption, other
- Remarks:
- further information on adsorption / desorption
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Referenceopen allclose all
See appendices attached.
Description of key information
The absorption coefficient of the test item has been determined to be > 4.27 x10E+05, Log Koc ≥ 5.63 (OECD 121 and EU Method C.19).
Key value for chemical safety assessment
- Koc at 20 °C:
- 427 000
Additional information
Test Guidance
OECD Guideline No. 121 and EC Method C.19
Method and material
The determination was carried out using the HPLC screening method.
Results
The absorption coefficient of the test item has been determined to be > 4.27 x 10E+05, Log Koc ≥ 5 .63.
Conclusion
The test substance has low mobility in soil.
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