Registration Dossier
Registration Dossier
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EC number: 217-316-1 | CAS number: 1809-19-4
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in chemico
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2017
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR Toolbox v.4.0 prediction.
Data source
Reference
- Reference Type:
- other: QSAR toolbox report
- Title:
- Toolbox report
- Year:
- 2 017
- Bibliographic source:
- QSAR Toolbox 4.0.0.26167
Materials and methods
- Principles of method if other than guideline:
- OECD Toolbox has assessed the reactivity of the substance looking for possible alerts on sensitisation; a category of similar substances was defined taking into account organic functional groups.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dibutyl phosphonate
- EC Number:
- 217-316-1
- EC Name:
- Dibutyl phosphonate
- Cas Number:
- 1809-19-4
- Molecular formula:
- C8H19O3P
- IUPAC Name:
- dibutyl phosphonate
- Test material form:
- liquid
Constituent 1
Results and discussion
In vitro / in chemico
Results
- Remarks on result:
- other:
- Remarks:
- no alert was identified as per the QSAR Toolbox v4.2 report
Any other information on results incl. tables
Table 1: Results of generation of general mechanistic and endpoint specific profiles of the test item using QSAR Toolbox 4.2.
| General Mechanistic Alerts | |
| Protein binding by OASIS | no alert found |
| Protein binding by OECD | no alert found |
| Protein binding potency Cys | DPRA less than 9 %: no protein binding alert |
| Protein binding potency Lys | DPRA less than 9 %: no protein binding alert |
| Protein binding potency by GHS | not possible to classify according to these rules (GHS) |
| Endpoint Specific Alerts | |
| Keratinocyte gene expression | not possible to classify according to these rules |
| Protein binding alerts for skin sensitisation according to GHS | no alert found |
| Protein binding alerts for skin sensitisation by OASIS | no alert found |
| Protein binding potency h-CLAT | no alert found |
| Respiratory sensitisation | no alert found |
Applicant's summary and conclusion
- Interpretation of results:
- other: No alerts detected for sensitisation
- Conclusions:
- Not a sensitiser
- Executive summary:
OECD Toolbox makes the assessment based on other existing databases and by analysing the reactivity of the molecule.
By analysing the general reactivity of the molecule, no alerts have been detected that may trigger concern for sensitisation potential.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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