Poly(oxy-1,2-ethanediyl), .alpha.-sulfo-.omega.-hydroxy-, C10-12-alkyl ethers, sodium salts

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

short-term toxicity to fish

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

12 SEP - 16 SEP 1994

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Please refer to the Category Approach Justification provided in Section 13

Qualifier:

according to guideline

Guideline:

other: EG Guideline 92/69 C.1

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

yes

Analytical monitoring:

yes

Vehicle:

no

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Details on test organisms:

TEST ORGANISM
- Common name: zebrafish
- Source: West Aquarium, Bad Lauterberg, Germany
- Length at study initiation (length definition, mean, range and SD): 3 cm +/- 0.5 cm
- Weight at study initiation (mean and range, SD): approximately 0.25 g
- Feeding during test
- Food type: no feeding


ACCLIMATION
- Acclimation period: 14 days
- Type and amount of food: TetraMin at a concentration of 1% of body weight
- Feeding frequency: daily
- Health during acclimation (any mortality observed): <= 5% seven days prior test until test start

Test type:

flow-through

Water media type:

freshwater

Limit test:

no

Total exposure duration:

96 h

Hardness:

11 ° dH

Test temperature:

19 °C - 20 °C

pH:

8.0 - 8.2

Dissolved oxygen:

80% - 99%

Nominal and measured concentrations:

nominal: 4.3, 6.0, 8.5, 11.8 and 17.1
mean measured (over 96 h): 4.6, 6.8, 13.9, 12.1 and 17.2

Details on test conditions:

TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: approximately 45 L aquaria
- Aeration: continuously
- Renewal rate of test solution (frequency/flow rate): approximately 10 L/h
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 10



TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: drinking water - Gelsenwasser AG


OTHER TEST CONDITIONS
- Photoperiod: 16 h light / 8 h darkness

Reference substance (positive control):

no

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

7.1 mg/L

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Reference 2

Endpoint:

short-term toxicity to fish

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

Please refer to the Category Approach Justification provided in Section 13

Reason / purpose for cross-reference:

read-across source

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

7.1 mg/L

Nominal / measured:

nominal

Conc. based on:

act. ingr.

Basis for effect:

mortality (fish)

Description of key information

LC50 (96 h) for Danio rerio = 7.1 mg a.i./L (nominal, OECD 203).

Additional information

The assessment is based on the data currently available. New studies, based on the category review and the final decisions issued for some of the category substances, which are also relevant for this assessment, are currently being conducted. The hazard assessment with respect to aquatic toxicity will be updated once all ongoing studies have been finalised.

No acute fish studies on toxic effects of AES (C10 -12, 1 -2.5EO) Na (CAS 68610 -66 -2) are available. Therefore, a read-across approach from a structural comparable AES (C12 -14, 2.5EO) mixture was applied as a worst case scenario.

The study was performed according to OECD guideline 203 in compliance with GLP requirements. Under flow-through conditions zebra fish (Danio rerio) were exposed to AES (C12-14, 1-2.5EO) Na (CAS 68891-38-3). After 96 h a LC50 of 7.1 mg a.i./L (nominal) was determined (Sasol, 1995).