(1α,2β,4β,6α)-2,2,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only a very brief report in a secondary source is available on the unspecified isomer. Primary Russian publication (Volkova et al. 1998) could not be obtained

Data source

Reference

Reference 1

Reference Type:

publication

Title:

[unknown]

Author:

Volkova NV et al.

Year:

1998

Bibliographic source:

Vrednie chemichescie veshestva. Prirodnie organicheskie soedinenia (Hazardous substances. Nature products), 285

Reference 2

Reference Type:

secondary source

Title:

Unnamed

Year:

2003

Materials and methods

Principles of method if other than guideline:

No data on methodology given in secondary source.

GLP compliance:

not specified

Test type:

other: no data

Test material

Test material information

Constituent 1

Reference substance name:

alpha pinene epoxide (unspecified isomer)

IUPAC Name:

alpha pinene epoxide (unspecified isomer)

Constituent 2

Reference substance name:

2,7,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane

EC Number:

216-869-6

EC Name:

2,7,7-trimethyl-3-oxatricyclo[4.1.1.02,4]octane

Cas Number:

1686-14-2

IUPAC Name:

2,7,7-trimethyl-3-oxatricyclo[4.1.1.0~2,4~]octane

Test material form:

not specified

Details on test material:

- Name of test material (as cited in study report): pinane, 2,3-epoxy-
- Molecular formula (if other than submission substance): C10-H16-O
- Molecular weight (if other than submission substance): 152.235
- Smiles notation (if other than submission substance): C1([C@@H]2[C@@]3(O[C@@H]3C[C@@H]1C2)C)(C)C
- InChl (if other than submission substance): 1S/C10H16O/c1-9(2)6-4-7(9)10(3)8(5-6)11-10/h6-8H,4-5H2,1-3H3
- Structural formula attached as image file (if other than submission substance): see Fig. 1
- Substance type: no data in citing source
- Physical state: no data in citing source
- Analytical purity: no data in citing source
- Impurities (identity and concentrations): no data in citing source
- Composition of test material, percentage of components: no data in citing source
- Isomers composition: no data in citing source
- Purity test date: no data in citing source
- Lot/batch No.: no data in citing source
- Expiration date of the lot/batch: no data in citing source
- Stability under test conditions: no data in citing source
- Storage condition of test material: no data in citing source

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

not specified

Vehicle:

not specified

Analytical verification of test atmosphere concentrations:

not specified

Remarks on duration:

No data in citing source

Concentrations:

No data in citing source

No. of animals per sex per dose:

No data in citing source

Control animals:

not specified

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC50

Effect level:

3 900 mg/m³ air

Based on:

not specified

Remarks on result:

other: No exposure duration or confidence intervals given

Applicant's summary and conclusion

Interpretation of results:

toxic

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

A secondary source (RTECS) provides limited details of an acute inhalation toxicity study conducted on rats given pinene alpha epoxide (unspecified isomer). The reported LC50 was 3900 mg/m3 (3.9 mg/L).

Executive summary:

A secondary source (RTECS) provides limited coverage of an acute inhalation toxicity study conducted on rats given pinene alpha epoxide (unspecified isomer). [The original Russian publication could not be obtained.] The reported LC50 was 3900 mg/m³ (3.9 mg/L).

According to the EU CLP and DSD regulations, alpha pinene epoxide (unspecified isomer) requires classification as toxic if inhaled and as harmful by inhalation, respectively, if assumed this is a reliable 4 -hr LC50 value.