Registration Dossier
Registration Dossier
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EC number: 418-310-3 | CAS number: 126050-54-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
The vapour pressure was estimated to be 3.2E-19 Pa at 25°C. From this it can be concluded that the vapour pressure of the test substance is too low to have any relevant effect on humans via the inhalation exposure route.
Approximately 10% of the substance is not inhalable due to its large particle size (>100µm).
The remainder of the substance falls within the inhalable range (>10µm) and could be a concern for acute toxicity, however in-vivo acute toxicity tests via dermal and oral administration show no acute toxic effects and therefore testing via inhalation is considered to be unnecessary.
No significant amount of test substance is in the respirable range (<10µm) and therefore there is no concern for chronic toxicity for inhalation exposure.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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