(3-(4-((((3β)-cholest-5-en-yl)oxy)carbonyl)phenoxy)propylmethyl-co-3-(4-((2-methyl-2-propenoyloxy)phenyloxy)carbonyl)-phenoxy)propylmethyl)cyclotetrasiloxane)

Hydrolysis

Administrative data

Endpoint:

hydrolysis

Adequacy of study:

other information

Data source

Reference

Reference Type:

other:

Title:

Unnamed

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other:

Results and discussion

Dissipation DT50 of parent compound

Dissipation DT50 of parent compound 1

pH:

4

Temp.:

50 °C

Hydrolysis rate constant:

0.02 s-1

DT50:

50.91 h

Dissipation DT50 of parent compound 2

pH:

4

Temp.:

65 °C

Hydrolysis rate constant:

0.01 s-1

DT50:

102.15 h

Dissipation DT50 of parent compound 3

pH:

7

Temp.:

50 °C

Hydrolysis rate constant:

0.04 s-1

DT50:

20.97 h

Dissipation DT50 of parent compound 4

pH:

7

Temp.:

65 °C

Hydrolysis rate constant:

0.02 s-1

DT50:

57.46 h

Dissipation DT50 of parent compound 5

pH:

9

Temp.:

50 °C

Hydrolysis rate constant:

0.02 s-1

DT50:

50.56 h

Dissipation DT50 of parent compound 6

pH:

9

Temp.:

65 °C

Hydrolysis rate constant:

0.03 s-1

DT50:

48.87 h