Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 627-199-2 | CAS number: 120728-10-1
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 Sep 2020 to 04 Dec 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 021
- Report date:
- 2021
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Version / remarks:
- March 2016
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- July 1995
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Version / remarks:
- March 1988
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 1-[(tert-butoxycarbonyl)amino]cyclobutane-1-carboxylic acid
- EC Number:
- 627-199-2
- Cas Number:
- 120728-10-1
- Molecular formula:
- C10H17NO4
- IUPAC Name:
- 1-[(tert-butoxycarbonyl)amino]cyclobutane-1-carboxylic acid
- Test material form:
- solid: particulate/powder
- Details on test material:
- Physical state: powder
Appearance: white powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot/batch number of test material: AC07N1912008
- Expiry date: 02 January 2021 (retest date)
- Physical Description: Almost white powder
- Purity: 98.9%
- Purity correction factor: 1.00
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: At room temperature
- Stability under storage conditions: not indicated
- Stability under test conditions: not indicated
- Solubility and stability of the test item in the solvent/vehicle: not applicable
Results and discussion
Water solubility
- Key result
- Water solubility:
- 4.79 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- >= 3 - <= 3.1
- Details on results:
- Preliminary test
The content of test item dissolved in the water sample was 4.57 g/L.
Main study
The results for the samples taken at 24, 48 and 76 hours are given in the table below.
The maximum difference of the concentrations determined in the 24, 48 and 76 hour test samples was ≤ 15%. Based on this, the water solubility of the test item is given as the mean value of the analyzed concentrations.
A small response at the retention time of the test item was detected in the chromatograms of the pretreated sample from the blank water mixture. It was considered to derive from carryover in the analytical system since similar responses were found in the analytical blanks.
Any other information on results incl. tables
Water Solubility of the Test Item
Stirring time [hours] | Analyzed concentration
| Mean | Maximum difference[%] | pH |
24 | 4.69 | 0 | 3.5 | 3.0 |
48 | 4.86 | 3.1 | ||
76 | 4.81 | 3.1 |
Applicant's summary and conclusion
- Conclusions:
- The flask method was applied for the determination of the water solubility of JNJ-63543883-AAA (T003661).
The water solubility of the test item at 20°C was 4.79 g/L.
The pH of the aqueous samples was 3.0 - 3.1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
