Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 436 (Acute Inhalation Toxicity: Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- fixed concentration procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Product obtained by rectification during the manufacturing process of Dihydromyrcenol
- Molecular formula:
- C10H18
- IUPAC Name:
- Product obtained by rectification during the manufacturing process of Dihydromyrcenol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Food availability: Ad libitum
Drinking water: Tap water
Watering: Bottles
Quality control: Certificate of analysis will be included in the final report
Water availability: Ad libitum
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Vehicle:
- air
- Details on inhalation exposure:
- Oxygen concentration in the exposure chamber will be at least 19% and carbon dioxide will not exceed 1%.
- Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Gravimetric determination of the aerosol concentration
- Duration of exposure:
- ca. 4 h
- No. of animals per sex per dose:
- 6 animals for the first step (3 males and 3 females) and 2 spare animals. Each additional step will contain 3 males and 3 females.
- Control animals:
- yes
- Details on study design:
- - Observation period of at least 14 days
- Frequency of observations and weighing: No diet or drinking water will be available during exposure.
- Necropsy of survivors performed: yes/no
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- ca. 10 mg/L air (nominal)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Clinical signs:
- other:
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
