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EC number: 811-889-7 | CAS number: 1350653-26-7
Vapour pressure
Administrative data
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018-12-03- to 2018-12-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- GLP compliance:
- no
- Type of method:
- effusion method: isothermal thermogravimetry
Test material
- Reference substance name:
- 5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
- EC Number:
- 811-889-7
- Cas Number:
- 1350653-26-7
- Molecular formula:
- C14 H8 F2 N4
- IUPAC Name:
- 5-fluoro-1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile
- Test material form:
- solid
Constituent 1
Results and discussion
Vapour pressure
- Key result
- Temp.:
- 20 °C
- Vapour pressure:
- 0.008 Pa
- Remarks on result:
- other: The determined vapour pressure is expected to be overestimated because the vapour pressure of molten material is higher than the vapour pressure of solid material.
Applicant's summary and conclusion
- Conclusions:
- The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of Fluorpyridonitril.
A value of the vapour pressure of the test item was determined using the data obtained between 130 °C and 160 °C. The vapour pressure of the test item was calculated (mean of three determinations) to: 0.00837 Pa at 20 °C.
This value however is expected to be overestimated, because it was determined from the molten material. - Executive summary:
Title: Fluorpyridonitril: Determination of the Vapour Pressure by Isothermal Thermogravimetry
Guidelines/Recommendations
This study was based on the procedures indicated by the following internationally accepted methods:
European Community (EC), EC No. 761/2009, Part A: Methods for the Determination of Physico-Chemical Properties, Guideline A.4: “Vapour Pressure”, Official Journal of the European Union No. L220, August 24, 2009
Organisation for Economic Co-operation and Development (OECD), OECD Guidelines for the Testing of Chemicals No. 104: “Vapour Pressure”, March 23, 2006
Purpose:
The purpose of the study was to determine the vapour pressure of the test item using the isothermal thermogravimetric effusion method. The evaporation rates of the test item at elevated temperatures and ambient pressure were determined by monitoring the weight loss over the time.
Results / Conclusion:
The isothermal thermogravimetric effusion method was applied for the determination of the vapour pressure of Fluorpyridonitril.
A value of the vapour pressure of the test item was determined using the data obtained between 130 °C and 160 °C. The vapour pressure of the test item was calculated (mean of three determinations) to: 0.00837 Pa at 20 °C.
This study is classified acceptable and satisfies the guideline requirements for vapour pressure studies.
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