Registration Dossier
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EC number: 422-630-9 | CAS number: 22208-25-9
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on test solutions:
- Identity and concentration of auxiliary solvent for dispersal: The test substance was dissolved directly in the test medium.
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg CaCO3/L
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The concentrations determined at the end of the test were 97 % of nominal. Considering this, it was concluded that the concentrations analysed were in agreement with the concentrations prepared and that the concentrations did not
change by more than 20 % during performance of the test. - Validity criteria fulfilled:
- not specified
- Conclusions:
- The EC50 (48h) of the test item in Daphnia magna was determined to be higher than 100 mg/L.
- Executive summary:
The study was conducted according EU Method C.2 (GLP study). Daphnia magna was exposed to the substance up to 48 hours. The concentrations determined at the end of the test were 97 % of nominal. The results showed that, as no daphnids became immobile during the 48-hour test period, the the EC50 was higher than 100 mg/L (maximum tested concentration).
Reference
Description of key information
Key study: EU Method C.2 (GLP study). The EC50 (48h) of the test item in Daphnia magna was determined to be higher than 100 mg/L (basis for effect: mobility).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- EC50
- Effect concentration:
- > 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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