Zinc EDDHA

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10 May 2021

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Principles of method if other than guideline:

The water solubility of substances with an expected high solubility is normally determined according to the flask method described in OECD Guidelines for the Testing of Chemicals, Method No. 105. To apply this method, the preparation of saturated solutions of the test item in water is required. Since this is not possible for this item, because it consists of a mixture and the Guideline is only applied for pure substances, a homemade method adapted from the preliminary test of the mentioned OECD Guideline is applied to investigate high complete miscibility.
The determination of the water solubility of the test item was performed using a gravimetric method.
Twelfe loading rates around the expected solubility in the range of 100 - 430 g/L were chosen for the test. After shaking for 3 days, the solutions were centrifuged and the residues were weighted after drying in order to determine the undissolved part of the test item.

GLP compliance:

no

Type of method:

other: gravimetric method

Water solubility:

> 400 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

200 g/L

Incubation duration:

3 d

Temp.:

20 °C

Remarks on result:

other: pH not mentioned in the report

Solubility results

Masst Test Item [g]	Nominal Concentration [g/L]	Visual observation	Undissolved residue [g]	Undissolved part [%]	Dissolved part [%]
1.0008	100.1	Completely dissolved	no residue	< 0.01	> 99.99
1.3003	130.0
1.6012	160.1
1.8984	189.8
2.2034	220.3
2.5009	250.1
2.8061	280.6
3.0996	310.0
3.4048	340.5
3.7002	370.0
4.0032	400.3
4.3007	430.1

The dissolved part of the test item was higher than 99.9 % for the nominal load of the test item 100 - 430 g/L. The solubility of the test item in water was stated as higher than 400g/L

Conclusions:

The dissolved part of the test item was higher than 99.9 % for the nominal load of the test item 100 - 430 g/L. The solubility of the test item in water was stated as higher than 400g/L.

Executive summary:

The water solubility of substances with an expected high solubility is normally determined according to the flask method described in OECD Guidelines for the Testing of Chemicals, Method No. 105. To apply this method, the preparation of saturated solutions of the test item in water is required. Since this is not possible for this item, because it consists of a mixture and the Guideline is only applied for pure substances, a homemade method adapted from the preliminary test of the mentioned OECD Guideline is applied to investigate high complete miscibility.

The determination of the water solubility of the test item was performed using a gravimetric method.

Twelve loading rates around the expected solubility in the range of 100 - 430 g/L were chosen for the test. After shaking for 3 days, the solutions were visually controlled and centrifuged and the residues were weighted after drying in order to determine the undissolved part of the test item. After centrifugation no undissolved particles were observed in the range of 100 - 430 g/L of the test item, therefore the solubility of the test item in water is stated as > 400 g/L at a temperature of 20 °C.

Description of key information

The water solubility of substances with an expected high solubility is normally determined according to the flask method described in OECD Guidelines for the Testing of Chemicals, Method No. 105. To apply this method, the preparation of saturated solutions of the test item in water is required. Since this is not possible for this item, because it consists of a mixture and the Guideline is only applied for pure substances, a homemade method adapted from the preliminary test of the mentioned OECD Guideline is applied to investigate high complete miscibility.

The determination of the water solubility of the test item was performed using a gravimetric method.

Twelve loading rates around the expected solubility in the range of 100 - 430 g/L were chosen for the test. After shaking for 3 days, the solutions were visually controlled and centrifuged and the residues were weighted after drying in order to determine the undissolved part of the test item. After centrifugation no undissolved particles were observed in the range of 100 - 430 g/L of the test item, therefore the solubility of the test item in water is stated as > 400 g/L at a temperature of 20 °C.

Key value for chemical safety assessment

Water solubility:

400 g/L

at the temperature of:

20 °C

Additional information

The above mentioned value is regarded as a worst case value, as the detected water solubility is higher than 400 g/L.