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EC number: 954-921-6 | CAS number: -
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 Dec 2016 to 15 Dec 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC method MT 157.3 (water solubility: flask method)
- GLP compliance:
- yes
- Medium:
- acetone
- Solubility:
- 270 g/L
- Temp.:
- 25 °C
- Medium:
- other: dichloromethane
- Solubility:
- 400 g/L
- Temp.:
- 25 °C
- Medium:
- ethyl acetate
- Solubility:
- 190 g/L
- Temp.:
- 25 °C
- Medium:
- other: hexane
- Solubility:
- 39 g/L
- Temp.:
- 25 °C
- Medium:
- methanol
- Solubility:
- 75 g/L
- Temp.:
- 25 °C
- Medium:
- n-octanol
- Solubility:
- 17 g/L
- Temp.:
- 25 °C
- Medium:
- toluene
- Solubility:
- 33 g/L
- Temp.:
- 25 °C
- Test substance stable:
- yes
- Conclusions:
- The solubility in five different organic solvents has been determined ranged from 17 g/L in octanol to 400 g/L in dichloromethane
- Executive summary:
The solubility of the test substance has been determined in seven organic solvents. As there is no general method available for the determination of the solubility in organic solvents, a procedure similar to that described in CIPAC method MT 157.3 (water solubility: flask method) was used in this study under GLP conditions. The solubilities determined at 25 °C and quoted to two significant figures are as follows: 270 g/Lf or acetone, 400 g/L for dichloromethane , 190 g/L for ethyl acetate, 39 mg/L for hexane, 75 g/L methanol, 17 g/L octanol and 33 g/L toluene.
Reference
Table 1: Results of solubility testing
Acetone |
25.3272 g of test substance dispersed in 50.0 mL of solvent |
||
equilibrium time at 25 °C |
1 day |
2 days |
|
solubility (g/L) |
264.562 |
270.373 |
|
solubility (g/L) |
270 |
||
Dichloromethane |
25.4140 g of test substance dispersed in 50.0 mL of solvent |
||
equilibrium time at 25 °C |
1 day |
2 days |
|
solubility (g/L) |
396.381 |
393.741 |
|
solubility (g/L) |
400 |
||
Ethyl Acetate |
24.3163 g of test substance dispersed in 50.0 mL of solvent |
||
equilibrium time at 25 °C |
1 day |
2 days |
|
solubility (g/L) |
186.088 |
197.049 |
|
solubility (g/L) |
190 |
||
Hexane |
20.4749 g of test substance dispersed in 50.0 mL of solvent |
||
equilibrium time at 25 °C |
1 day |
2 days |
|
solubility (g/L) |
39.308 |
37.983 |
|
solubility (g/L) |
39 |
||
Methanol |
25.1267 g of test substance dispersed in 50.0 mL of solvent |
||
equilibrium time at 25 °C |
1 day |
2 days |
|
solubility (g/L) |
75.193 |
74.678 |
|
solubility (g/L) |
75 |
||
Octanol |
25.1326 g of test substance dispersed in 50.0 mL of solvent |
||
equilibrium time at 25 °C |
1 day |
2 days |
|
solubility (g/L) |
16.982 |
16.907 |
|
solubility (g/L) |
17 |
||
Toluene |
24.9029 g of test substance dispersed in 50.0 mL of solvent |
||
equilibrium time at 25 °C |
1 day |
2 days |
|
solubility (g/L) |
33.735 |
32.935 |
|
solubility (g/L) |
33 |
||
Description of key information
The test substance can be considered completely miscible in organic solvents and the solubility ranged from 17 g/L in octanol to 400 g/L in dichloromethane. Vijayakumar 2017
Key value for chemical safety assessment
Additional information
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