4-(5-(3,5-dichloro-4-fluorophenyl)-5-(trifluoromethyl)-4,5-dihydro-1,2-oxazol-3-yl)-N-(2-ethyl-3-oxo-1,2-oxazolidin-4-yl)-2-methylbenzamide

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 Dec 2016 to 15 Dec 2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

according to guideline

Guideline:

other: CIPAC method MT 157.3 (water solubility: flask method)

GLP compliance:

yes

Medium:

acetone

Solubility:

270 g/L

Temp.:

25 °C

Medium:

other: dichloromethane

Solubility:

400 g/L

Temp.:

25 °C

Medium:

ethyl acetate

Solubility:

190 g/L

Temp.:

25 °C

Medium:

other: hexane

Solubility:

39 g/L

Temp.:

25 °C

Medium:

methanol

Solubility:

75 g/L

Temp.:

25 °C

Medium:

n-octanol

Solubility:

17 g/L

Temp.:

25 °C

Medium:

toluene

Solubility:

33 g/L

Temp.:

25 °C

Test substance stable:

yes

Table 1: Results of solubility testing

Acetone	25.3272 g of test substance dispersed in 50.0 mL of solvent
	equilibrium time at 25 °C	1 day	2 days
	solubility (g/L)	264.562	270.373
	solubility (g/L)	270
Dichloromethane	25.4140 g of test substance dispersed in 50.0 mL of solvent
	equilibrium time at 25 °C	1 day	2 days
	solubility (g/L)	396.381	393.741
	solubility (g/L)	400
Ethyl Acetate	24.3163 g of test substance dispersed in 50.0 mL of solvent
	equilibrium time at 25 °C	1 day	2 days
	solubility (g/L)	186.088	197.049
	solubility (g/L)	190
Hexane	20.4749 g of test substance dispersed in 50.0 mL of solvent
	equilibrium time at 25 °C	1 day	2 days
	solubility (g/L)	39.308	37.983
	solubility (g/L)	39
Methanol	25.1267 g of test substance dispersed in 50.0 mL of solvent
	equilibrium time at 25 °C	1 day	2 days
	solubility (g/L)	75.193	74.678
	solubility (g/L)	75
Octanol	25.1326 g of test substance dispersed in 50.0 mL of solvent
	equilibrium time at 25 °C	1 day	2 days
	solubility (g/L)	16.982	16.907
	solubility (g/L)	17
Toluene	24.9029 g of test substance dispersed in 50.0 mL of solvent
	equilibrium time at 25 °C	1 day	2 days
	solubility (g/L)	33.735	32.935
	solubility (g/L)	33

 

Conclusions:

The solubility in five different organic solvents has been determined ranged from 17 g/L in octanol to 400 g/L in dichloromethane

Executive summary:

The solubility of the test substance has been determined in seven organic solvents. As there is no general method available for the determination of the solubility in organic solvents, a procedure similar to that described in CIPAC method MT 157.3 (water solubility: flask method) was used in this study under GLP conditions.  The solubilities determined at 25 °C and quoted to two significant figures are as follows: 270 g/Lf or acetone, 400 g/L for dichloromethane , 190 g/L for ethyl acetate, 39 mg/L for hexane, 75 g/L methanol, 17 g/L octanol and 33 g/L toluene.

Description of key information

The test substance can be considered completely miscible in organic solvents and the solubility ranged from 17 g/L in octanol to 400 g/L in dichloromethane. Vijayakumar 2017