Registration Dossier
Registration Dossier
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EC number: 221-650-3 | CAS number: 3177-22-8
Endpoint summary
Administrative data
Description of key information
Not skin sensitising.
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Additional information:
No experimental data on the skin sensitising potential of target substance was found in literature.
The OECD QSAR Toolbox (v. 4.0.0.26167) was used to identify structural alerts. In particular:
- protein binding by OASIS v1.4: no alert found
- protein binding by OECD: no alert found
- protein binding potency Cys (DPRA 13 %): DPRA less than 9 % (DPRA 13 %)
- protein binding potency Lys (DPRA 13 %) : DPRA less than 9 % (DPRA 13 %)
- protein binding alerts for skin sensitisation: no alert found
- protein binding potency h-CLAT: no alert found.
The Vega-qsar tool was run on the acid form of the target substance (CAS 88 -63 -1, EC 201 -846 -5), as not applicable to salts. A representative structural analogue identified in the Vega database (CAS 121 -57 -3) resulted to be non-sensitising experimentally.
Further inormation are available in the attachment in IUCLID section 13.2.
Justification for classification or non-classification
Based on results provided by QSAR tools and available data on structural analogues, the substance is not classified as skin sensitising within the CLP Regulation (EC 1272/2008).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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