2-[bis(2-hydroxyethyl)amino]-2-(hydroxymethyl)-1,3-propanediol hydrochloride

Boiling point

Link to relevant study record(s)

Reference

Endpoint:

boiling point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2020-06-15 to 2020-06-16

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 103 (Boiling Point)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.2 (Boiling Temperature)

Version / remarks:

2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

differential scanning calorimetry

Key result

Decomposition:

yes

Decomp. temp.:

ca. 170 °C

Measurement No.	Sample weight / mg	Onset of Effect / °C	Range of effect / °C	Weight loss / mg	Atmospheric pressure / hPa
PN19837	8.42	72.14 108.69 ---	60 – 90 (endo) 100 – 120 (endo) 170 – 280 (exo)	7.70	1004.2
PN19838	12.21	71.23 100.88 ---	60 – 100 (endo) 100 – 120 (endo) 170 – 270 (exo)	10.67	1004.2

 

Starting at a temperature of 60 °C a first endothermic effect could be observed, which was followed by second endothermic effect starting at a temperature of 100 °C. The test item showed an exothermic effect starting at a temperature of 170 °C with an average energy release of -160 J/g.

As none of the endothermic effects could be clearly assigned to a melting or boiling of the test item, the capillary method was performed in order to visually investigate if there is a melting or boiling up to a temperature of 215 °C. The test item turned transparent and started to melt at a temperature of approx. 70 °C. Due to the fact that bubbles were encapsulated during the melting process, no clear meniscus could be observed. At a temperature of 120 °C the test item was completely molten. Starting at a temperature of 190 °C the test item rose up in the capillary and changed its color to yellow.

Due to the observations in the measurements using the capillary method, it can be stated that the test item has a melting range between 70 and 120 °C as well as no boiling point up to its decomposition starting at a temperature of approx. 170 °C.

Conclusions:

No boiling point could be estimated because the test item decomposed. The decomposition temperature was found to be 170 °C.

Executive summary:

The boiling point of the test item was determined by Differential Scanning Calorimetry and the capillary method according to Regulation (EC) No 440/2008 Method A.2. and OECD Test Guideline 103 (1995). In the DSC measurement the first endothermic effect could be observed at 60 °C, which was followed by second endothermic effect starting at a temperature of 100 °C. The test item showed an exothermic effect starting at a temperature of 170 °C with an average energy release of -160 J/g. As none of the endothermic effects could be clearly assigned to a melting or boiling of the test item, the capillary method was performed in order to visually investigate if there is a melting or boiling up to a temperature of 215 °C. The test item turned transparent and started to melt at a temperature of approx. 70 °C. The test item was completely molten at 120 °C. Due to this observation, it can be stated that the test item has a melting range between 70 and 120 °C as well as no boiling point up to its decomposition starting at a temperature of approx. 170 °C.

Description of key information

No boiling point could be estimated because the test item decomposed. The decomposition temperature was found to be 170 °C (reference 4.3-1).

Additional information

The boiling point of the test item was determined by Differential Scanning Calorimetry and the capillary method according to Regulation (EC) No 440/2008 Method A.2. and OECD Test Guideline 103 (1995). In the DSC measurement the first endothermic effect could be observed at 60 °C, which was followed by second endothermic effect starting at a temperature of 100 °C. The test item showed an exothermic effect starting at a temperature of 170 °C with an average energy release of -160 J/g. As none of the endothermic effects could be clearly assigned to a melting or boiling of the test item, the capillary method was performed in order to visually investigate if there is a melting or boiling up to a temperature of 215 °C. The test item turned transparent and started to melt at a temperature of approx. 70 °C. The test item was completely molten at 120 °C. Due to this observation, it can be stated that the test item has a melting range between 70 and 120 °C as well as no boiling point up to its decomposition starting at a temperature of approx. 170 °C.