Registration Dossier
Registration Dossier
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EC number: 900-021-3 | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 44 Days
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
- EC Number:
- 900-021-3
- Molecular formula:
- 3,5-Heptanedione-1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl) :C20 H22O5, 3,5-Heptanedione-1,7 -bis(4-hydroxyphenyl) : C19H20O4, 3,5-Heptanedione-1,7-bis(4-hydroxy-3-methoxyphenyl) : C21H24O6
- IUPAC Name:
- 1,7-bis(4-hydroxy-3-methoxyphenyl)heptane-3,5-dione
- Test material form:
- solid: crystalline
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- water
- Controls:
- yes
- Duration of treatment / exposure:
- 24h
- Observation period (in vivo):
- 48h
- Number of animals or in vitro replicates:
- 3
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Vehicle controls validity:
- valid
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- no indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2B (mildly irritating to eyes) based on GHS criteria
- Conclusions:
- The test material falls under "Non Irritating" Category of UN GHS Classification.
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