Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
Reference
Description of key information
Key value for chemical safety assessment
Additional information
There are no long-term toxicity studies to fish available for Reaction mass of dipotassium 2-(3,4-dimethyl-1H-pyrazol-1-yl) succinate and dipotassium 2-(4,5-dimethy-1H-pyrazol-1-yl) succinate. However, read-across data available for fish, daphnia and algae determined no adverse effects up to the highest test concentration of 100 mg/L. In a chronic toxicity study available for the source substance determined a NOEC (21 d) of 11.1 mg/L (reproduction) was determined. According to the “Guidance on information requirements and chemical safety assessment Chapter R.7b: Endpoint specific guidance”, if invertebrates are likely to be more sensitive than fish and algae or the relative sensitivity of invertebrates cannot be predicted, long-term testing on Daphnia sp. should be preferred instead of fish (ECHA, 2017). As the NOEC values obtained with Daphnia as well as with algae are clearly above 1 mg/L, a long-term fish study is not considered necessary for hazard assessment. Furthermore the environmental exposure assessment for the substance indicates no risk for the aquatic compartment (all RCR< 1; please refer to Chapter 9 and 10 of the Chemical Safety Report for detailed information). Therfore, and for animal welfare reasons, no long-term tests with fish were carried out.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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