trans-2-(4-Bromo-3-fluorophenyl)-5-butyl-[1,3]dioxane

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

from 2018-10-24 to 2019-01-28

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

GLP compliance:

no

Type of method:

differential scanning calorimetry

Key result

Melting / freezing pt.:

38.9 °C

Decomposition:

no

Sublimation:

no

Two DSC measurements with a heating rate of 10 K/min up to the final temperature of 500 °C showed an endothermal effect (melting) in the temperature range of 30 - 50 °C. One additional DSC measurement with a heating rate of 10 K/min up to the final temperature of 100 °C showed an endothermal effect (melting) in the temperature range of 35 - 50 °C.

Table: Melting point (DSC measurements)

Ident No.	Test item / mg	Starting temperature / °C	Final temperature / °C	Temperature range (endothermal) / °C	Onset (melting) / °C	Crucible	Observations after measurement
38297	14.38	25	500	30 – 40	38.71	Aluminium with a hole	Crucible was empty, mass loss 100 %
38299	19.39	25	500	30 – 50	38.81	Aluminium with a hole	Crucible was empty, mass loss 100 %
38298	20.22	25	100	35 – 50	39.31	Aluminium with a hole	Test item was a clear solidified melt, no mass loss

The test item has a melting point of 38.9 °C

Conclusions:

The test item has a melting point of 38.9 °C.

Executive summary:

A study was conducted according to OECD TG 102 and Regulation (EC) No 440/2008 method A.1 to determine the melting point of the test item using differential scanning calorimetry. The test item was weighed into an aluminium crucible under an inert atmosphere (nitrogen). Three tests with about 14 - 20 mg of the test item were performed. As reference crucible, an empty aluminium crucible was used. Two DSC measurements with a heating rate of 10 K/min up to the final temperature of 500 °C showed an endothermal effect (melting) in the temperature range of 30 - 50 °C. One additional DSC measurement with a heating rate of 10 K/min up to the final temperature of 100 °C showed an endothermal effect (melting) in the temperature range of 35 - 50 °C. After the first two tests a 100 % mass loss was observed. After the additional test no mass loss was observed. Based on the results of the DSC-measurements it was concluded that the test item has a melting point of 38.9 °C.

Description of key information

The test item has a melting point of 38.9 °C.

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

38.9 °C

Additional information

A study was conducted according to OECD TG 102 and Regulation (EC) No 440/2008 method A.1 to determine the melting point of the test item using differential scanning calorimetry (reference 4.2-1). The test item was weighed into an aluminium crucible under an inert atmosphere (nitrogen). Three tests with about 14 - 20 mg of the test item were performed. As reference crucible, an empty aluminium crucible was used. Two DSC measurements with a heating rate of 10 K/min up to the final temperature of 500 °C showed an endothermal effect (melting) in the temperature range of 30 - 50 °C. One additional DSC measurement with a heating rate of 10 K/min up to the final temperature of 100 °C showed an endothermal effect (melting) in the temperature range of 35 - 50 °C. After the first two tests a 100 % mass loss was observed. After the additional test no mass loss was observed. Based on the results of the DSC-measurements it was concluded that the test item has a melting point of 38.9 °C.