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EC number: 452-330-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 29 January 2003 to 17 February 2003
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was performed to GLP and in line with the standardised guidelines OECD 105, EU Method A.6 and EPA OPPTS 830.7840 with no deviations thought to impact the reliability of the presented results.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- 1.6 g/L
- Temp.:
- 25 °C
- pH:
- >= 7.86 - <= 8.06
- Details on results:
- A comparison of the retention times of the test material in the reference solutions with those in the sample solutions indicated that the identity of the test material had not altered during the experiment.
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
Under the conditions of the test, the solubility of the test material was determined, using the shake-flask method, to be 1.6 g/L in pure water at 25 ºC. The study is considered to be reliable, relevant and adequate for risk assessment purposes. - Executive summary:
The solubility of the test material was determined in accordance with the standardised guidelines OECD 105, EU Method A.6 and EPA OPPTS 830.7480 using the shake-flask method. The solutions were analysed using HPLC. Under the conditions of the test, the solubility of the test material was determined to be 1.6 g/L in pure water at 25 ºC.
Reference
Table 1: Results
Sample number |
W1 |
W2 |
W5 |
W2 |
W4 |
W6 |
|
Amount of test item (g) dispersed in 12.5 mL of solvent |
0.2273 |
0.2344 |
0.2147 |
0.2251 |
0.2195 |
0.2486 |
|
Number of days at 30.0 °C |
3 |
2 |
1 |
3 |
2 |
1 |
|
Number of days at 25.0 °C |
1 |
1 |
1 |
1 |
1 |
1 |
|
Centrifugation time (minutes) |
40 |
40 |
40 |
40 |
40 |
40 |
|
Centrifugation speed (G value) |
30000 |
30000 |
30000 |
50000 |
50000 |
50000 |
|
pH of aqueous solution |
7.93 |
8.06 |
7.87 |
8.04 |
7.98 |
7.86 |
|
water solubility (g/L) |
|||||||
1st determination |
1.651 |
1.721 |
1.565 |
1.683 |
1.558 |
1.532 |
|
2nd determination |
1.663 |
1.724 |
1.586 |
1.690 |
1.573 |
1.536 |
|
average |
1.657 |
1.723 |
1.576 |
1.687 |
1.566 |
1.534 |
|
average (g/L) |
1.652 |
1.595 |
|||||
relative standard deviation (%) |
4.02 |
4.53 |
|||||
final average (g/L) |
1.6 |
||||||
final relative standard deviation (%) |
4.5 |
Description of key information
1.6 g/L, 25 °C, OECD TG 105, EU Method A.6, Das 2003
Key value for chemical safety assessment
- Water solubility:
- 1.6 g/L
- at the temperature of:
- 25 °C
Additional information
The solubility of the test material was determined in accordance with the standardised guidelines OECD 105, EU Method A.6 and EPA OPPTS 830.7480 using the shake-flask method. The solutions were analysed using HPLC. Under the conditions of the test, the solubility of the test material was determined to be 1.6 g/L in pure water at 25 ºC. The study was performed in line with GLP and an accepted standardised guideline with a high standard of reporting. The study was assigned a reliability score of Klimisch 1 and considered suitable for assessment as an accurate reflection of the test substance. The available data are considered complete and the result determined, 1.6 g/L at 25 °C, was taken forward for risk assessment.
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