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REACH

1,2-dimethoxyethane

EC number: 203-794-9 | CAS number: 110-71-4

Life Cycle description
Uses advised against

Toxicological information

Endpoint summary

Administrative data

Description of key information

In an in vivo rabbit study (OECD 404), 0.5 mL of EDGME were applied to the shaved skin for 24 hours under occlusive conditions. The observations conducted at 24, 48 and 72 hours after application showed the formation of severe erythema and mild eschar (total mean score = 2.33) and mild edema (mean total score = 0.72) in all animals. Other effects reported after 48 hours included dry, rough and hardened skin, raised skin and greenish coloration, hematoma of the lower layers of the skin at the site of application. The signs of irritation were not reversible within the observation period.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion

Endpoint conclusion:: adverse effect observed (irritating)

Additional information

Justification for classification or non-classification

The substance is classified as causes skin irritation (CLP Regulation - category 2)

Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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